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Linoleic acid metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
linoleic_acid + O2 <=> (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate 1.13.11.58 linoleate 9S-lipoxygenase
1.13.11.B6


(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate <=> (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate 5.4.4.6 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase

linoleic_acid + O2 <=> (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate 1.13.11.12 linoleate 13S-lipoxygenase
1.13.11.31 arachidonate 12-lipoxygenase
1.13.11.33 arachidonate 15-lipoxygenase
1.13.11.34 arachidonate 5-lipoxygenase




linoleic_acid + O2 + NADPH + H+ <=> (9Z)-12,13-epoxyoctadec-9-enoate + NADP+ + H2O 1.14.13
1.14.14
1.14.14.1 unspecific monooxygenase



linoleic_acid + 2 ferricytochrome_b5 + O2 + 2 H+ <=> crepenynate + 2 ferricytochrome_b5 + 2 H2O 1.14.19.39 acyl-lipid Delta12-acetylenase

(9Z)-12,13-epoxyoctadec-9-enoate + H2O <=> (9Z)-12,13-dihydroxyoctadec-9-enoic_acid 3.3.2
3.3.2.10 soluble epoxide hydrolase


(12Z,9R,10S)-9,10-epoxyoctadec-12-enoate + H2O <=> (12Z)-9,10-dihydroxyoctadec-12-enoic_acid 3.3.2

(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate <=> (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate 4.2.1.92 hydroperoxide dehydratase
5.4.4.5 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase


linoleic_acid + O2 <=> (8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate 1.13.11.62 linoleate 10R-lipoxygenase

phosphatidylcholine + H2O <=> lysophosphatidylcholine + linoleic_acid 3.1.1.4 phospholipase A2

linoleic_acid + O2 <=> (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate 1.13.11.45 linoleate 11-lipoxygenase

linoleic_acid + O2 <=> (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate 1.13.11.60 linoleate 8R-lipoxygenase

linoleic_acid <=> 9-cis,11-trans-linoleic_acid 5.2.1.5 linoleate isomerase

linoleic_acid + O2 + NADPH + H+ <=> (12Z,9R,10S)-9,10-epoxyoctadec-12-enoate + NADP+ + H2O 1.14.13
1.14.14
1.14.14.1 unspecific monooxygenase



linoleic_acid + reduced_acceptor + O2 <=> gamma-linolenic_acid + A + H2O 1.14.19.3 acyl-CoA 6-desaturase

13(S)-HODE + NAD+ <=> 13-OxoODE + NADH + H+ 1.1.1

Visualization of the pathway